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As a result, the metabolite is chargeable for about 20% of sildenafil's action. Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) also to a lesser extent inside the urine (all around thirteen% in the administered oral dose). If taken using a high-Excess fat food, absorption is lowered; enough time taken to succeed in the utmost plasma focus boosts by all-around just one hour, and the maximum focus by itself is diminished by practically 1-third.[52]

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Sono stati segnalati casi di improvvisa perdita dell’udito dopo l’uso di tadalafil. Sebbene in alcuni casi fossero presenti altri fattori di rischio (come l’età, il diabete, l’ipertensione e una precedente storia di perdita di udito) i pazienti devono essere avvertiti di interrompere l’assunzione di tadalafil e consultare immediatamente un medico in caso di improvvisa riduzione o perdita dell’udito.

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